USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PMVK_HUMAN USC-OGP 2-DE database:  PMVK_HUMAN PMVK_HUMAN General information about the entry View entry in simple text format Entry name PMVK_HUMAN Primary accession number Q15126 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Phosphomevalonate kinase; Short=PMKase; Short=hPMK; EC=2.7.4.2;. Gene name Name=PMVK Synonyms=PMKI Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1308: pI=5.85; Mw=22246 Cross-references UniProtKB/Swiss-Prot Q15126; PMVK_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PMVK_HUMAN Primary accession number Q15126 Secondary accession number(s) Q5TZW9 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 151) Name and origin of the protein Description RecName: Full=Phosphomevalonate kinase; Short=PMKase; Short=hPMK; EC=2.7.4.2; Gene name Name=PMVK Synonyms=PMKI Encoded on Name=PMVK; Synonyms=PMKI Keywords 3D-structure; ATP-binding; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Disease mutation; Kinase; Lipid biosynthesis; Lipid metabolism; Nucleotide-binding; Peroxisome; Polymorphism; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL L77213; AAC37593.1; -; mRNA EMBL BT019976; AAV38779.1; -; mRNA EMBL BC006089; AAH06089.1; -; mRNA EMBL BC007694; AAH07694.1; -; mRNA EMBL AF026069; AAC60791.1; -; Genomic_DNA CCDS CCDS1073.1; -; . RefSeq NP_006547.1; NM_006556.3; . UniGene Hs.30954; -; . PDB 3CH4; X-ray; 1.76 A; B=1-192 PDBsum 3CH4; -; . ProteinModelPortal Q15126; -; . SMR Q15126; -; . BioGrid 115897; 24; . IntAct Q15126; 3; . MINT MINT-7034566; -; . STRING 9606.ENSP00000357452; -; . GuidetoPHARMACOLOGY 641; -; . SwissLipids SLP:000001241; -; . iPTMnet Q15126; -; . PhosphoSitePlus Q15126; -; . BioMuta PMVK; -; . DMDM 3024422; -; . REPRODUCTION-2DPAGE IPI00220648; -; . EPD Q15126; -; . PaxDb Q15126; -; . PeptideAtlas Q15126; -; . PRIDE Q15126; -; . DNASU 10654; -; . Ensembl ENST00000368467; ENSP00000357452; ENSG00000163344; . GeneID 10654; -; . KEGG hsa:10654; -; . CTD 10654; -; . DisGeNET 10654; -; . GeneCards PMVK; -; . HGNC HGNC:9141; PMVK; . HPA HPA029900; -; . MalaCards PMVK; -; . MIM 175800; phenotype; . MIM 607622; gene; . neXtProt NX_Q15126; -; . OpenTargets ENSG00000163344; -; . PharmGKB PA33465; -; . eggNOG ENOG410IZWN; Eukaryota; . eggNOG ENOG4111IXB; LUCA; . GeneTree ENSGT00390000014801; -; . HOGENOM HOG000261666; -; . HOVERGEN HBG003277; -; . InParanoid Q15126; -; . KO K13273; -; . OMA KNDIKWF; -; . OrthoDB EOG091G0PNO; -; . PhylomeDB Q15126; -; . TreeFam TF312935; -; . BioCyc MetaCyc:HS08830-MONOMER; -; . BRENDA 2.7.4.2; 2681; . Reactome R-HSA-191273; Cholesterol biosynthesis; . Reactome R-HSA-2426168; Activation of gene expression by SREBF (SREBP); . SABIO-RK Q15126; -; . UniPathway UPA00057; UER00099; . ChiTaRS PMVK; human; . EvolutionaryTrace Q15126; -; . GenomeRNAi 10654; -; . PRO PR:Q15126; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000163344; -; . CleanEx HS_PMVK; -; . ExpressionAtlas Q15126; baseline and differential; . Genevisible Q15126; HS; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005777; C:peroxisome; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IDA:UniProtKB; . GO GO:0004631; F:phosphomevalonate kinase activity; IDA:UniProtKB; . GO GO:0006695; P:cholesterol biosynthetic process; IDA:UniProtKB; . GO GO:0019287; P:isopentenyl diphosphate biosynthetic process; mevalonate pathway; IBA:GO_Central GO GO:0070723; P:response to cholesterol; IEP:UniProtKB; . GO GO:0016126; P:sterol biosynthetic process; IDA:UniProtKB; . Gene3D 3.40.50.300; -; 1; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR005919; Pmev_kin_anim; . PANTHER PTHR13101; PTHR13101; 1; . Pfam PF04275; P-mevalo_kinase; 1; . PIRSF PIRSF036639; PMK_anim; 1; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR01223; Pmev_kin_anim; 1; .

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